erk-1/2 inhibitor 1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11226	ERK1/2 inhibitor 1		ERK
	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.		ERK
T8472	ERK1/2 inhibitor 2	ASTX-029,ASTX029	ERK
	ERK1/2 inhibitor 2 (ASTX029) is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.		ERK
T7506	Yoda 1		Piezo Channel
	Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)		Piezo Channel
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
T14894	CC-90003		ERK
	CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.		ERK
T36675	ERK Inhibitor
	ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 μM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-speci...
T11224	Rineterkib	ERK-IN-1	ERK , Raf
	Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.		ERK , Raf
T4091	Temuterkib	LY3214996	ERK
	Temuterkib (LY3214996) is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity.		ERK
T5727	CAFESTOL		ERK , NF-κB , COX , PGE Synthase
	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production...		ERK , NF-κB , COX , PGE Synthase
T8505	SC-236	Sc 236	Apoptosis , COX , PPAR
	SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).		Apoptosis , COX , PPAR
T20759	XRP44X	XRP-44-X,XRP 44X,XRP-44X,XRP 44 X	Ras
	XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.		Ras
T9428	HM43239		FLT
	HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the k...		FLT
T0005	Aspirin	Acetylsalicylate,Acetylsalicylic Acid,ASA	Mitophagy , Virus Protease , COX , Autophagy
	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...		Mitophagy , Virus Protease , COX , Autophagy
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T7005L	Ulixertinib hydrochloride	Ulixertinib HCl,BVD-523,VRT752271,BVD 523,BVD523,VRT 752271
	Ulixertinib is an inhibitor of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits...
T63708	Calpain-2-IN-1
	Calpain-2-IN-1 is a selective calpain-2 inhibitor that prolongs ERK activation and thus enhances learning and memory.
T11225	ERK-IN-2		ERK
	ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].		ERK
T79785	Laxiflorin B		ERK
	Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].		ERK
T79808	KRAS G12C inhibitor 61		ERK
	KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM. This inhibitor is applicable in the research of pancreatic, colorecta...		ERK
T78190	ERK1/2 inhibitor 9		ERK
	ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the reduction of phospho-ERK1/2 levels. When conjugated with trans-cy...		ERK